| Alternative title | CBIS-1 : Matériau de référence certifié de cannabis moulu et séché |
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| DOI | Resolve DOI: https://doi.org/10.4224/crm.2021.cbis-1 |
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| Author | Search for: McRae, Garnet1; Search for: Bates, Jennifer1; Search for: Meija, Juris1ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: Melanson, Jeremy1ORCID identifier: https://orcid.org/0000-0002-2290-0101 |
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| Affiliation | - National Research Council Canada
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| Format | 3D, Material |
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| Subject | Canadian reference material; CBIS-1; dried cannabis; Δ9-tetrahydrocannabinol (THC); Δ9-tetrahydrocannabinolic acid (THCA); cannabidiol (CBD); cannabidiolic acid (CBDA); cannabigerol (CBG); cannabigerolic acid (CBGA); cannabinol (CBN); cannabinolic acid (CBNA); cannabichromene (CBC); cannabichromenic acid (CBCA); tetrahydrocannabivarin (THCV); tetrahydrocannabivarinic acid (THCVA); cannabidivarin (CBDV); cannabidivarinic acid (CBDVA) |
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| Abstract | CBIS-1 is a certified reference material (CRM) designed for use in method development, validation, and quality control for the analysis of cannabinoids in cannabis. While cannabinoid solution reference standards are appropriate for instrument calibration, matrix CRMs such as CBIS-1 can help validate entire methods, from sampling, extraction, clean-up, and instrumental analysis. Certified values for the mass fraction of cannabinoids in CBIS-1 have been established. |
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| Analytes | View analytes| Analyte | Quantity | Value | Expanded uncertainty | Unit | Type |
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| Δ⁹-tetrahydrocannabinol (THC) | mass fraction | 48.9 | 6.4 | mg/g | certified | | Δ⁹-tetrahydrocannabinolic acid (THCA) | mass fraction | 124 | 7 | mg/g | certified | | total Δ⁹-tetrahydrocannabinol (total THC) | mass fraction | 158 | 9 | mg/g | certified | | cannabidiol (CBD) | mass fraction | 8.33 | 0.72 | mg/g | certified | | cannabidiolic acid (CBDA) | mass fraction | 23.0 | 1.0 | mg/g | certified | | total cannabidiol (total CBD) | mass fraction | 28.5 | 1.0 | mg/g | certified | | cannabigerol (CBG) | mass fraction | 1.78 | 0.18 | mg/g | certified | | cannabigerolic acid (CBGA) | mass fraction | 3.89 | 0.20 | mg/g | certified | | cannabinol (CBN) | mass fraction | 3.39 | 0.42 | mg/g | certified | | cannabinolic acid (CBNA) | mass fraction | 1.84 | 0.12 | mg/g | certified | | cannabichromene (CBC) | mass fraction | 1.02 | 0.08 | mg/g | certified | | cannabichromenic acid (CBCA) | mass fraction | 1.67 | 0.10 | mg/g | certified | | tetrahydrocannabivarin (THCV) | mass fraction | 0.252 | 0.026 | mg/g | certified | | tetrahydrocannabivarinic acid (THCVA) | mass fraction | 0.446 | 0.034 | mg/g | certified | | cannabidivarin (CBDV) | mass fraction | 0.0415 | 0.0038 | mg/g | certified | | cannabidivarinic acid (CBDVA) | mass fraction | 0.126 | 0.008 | mg/g | certified |
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| Publication date | 2021-03-01 |
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| Publisher | National Research Council of Canada |
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| Copyright statement | - © 2021 National Research Council of Canada
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| References | View items (5)- McRae, Garnet, and Jeremy E. Melanson. ‘Quantitative Determination and Validation of 17 Cannabinoids in Cannabis and Hemp Using Liquid Chromatography-Tandem Mass Spectrometry’. Analytical and Bioanalytical Chemistry 412, no. 27 (24 August 2020): 7381–93. https://doi.org/10.1007/s00216-020-02862-8.
- Mudge, Elizabeth M, and Paula N Brown. ‘Determination of Cannabinoids in Cannabis Sativa Dried Flowers and Oils by LC-UV: Single-Laboratory Validation, First Action 2018.10’. Journal of AOAC INTERNATIONAL 103, no. 2 (March 2020): 489–93. https://doi.org/10.5740/jaoacint.19-0197.
- Guide to the expression of uncertainty in measurement (GUM) (1 September 2008). https://www.bipm.org/utils/common/documents/jcgm/JCGM_100_2008_E.pdf.
- Meija, Juris, Garnet McRae, Christopher O. Miles, and Jeremy E. Melanson. ‘Thermal Stability of Cannabinoids in Dried Cannabis: A Kinetic Study’. Analytical and Bioanalytical Chemistry 414, no. 1 (8 January 2021): 377–84. https://doi.org/10.1007/s00216-020-03098-2.
- Veen, Adriaan M. H. van der. ‘Bayesian Analysis of Homogeneity Studies in the Production of Reference Materials’. Accreditation and Quality Assurance 22, no. 6 (2 November 2017): 307–19. https://doi.org/10.1007/s00769-017-1292-6.
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| Export citation | Export as RIS |
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| Collection | Canadian Reference Materials and Methods |
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| Record identifier | 335aa529-82d3-4744-9c85-525dfe7e3ac0 |
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| Record created | 2021-03-31 |
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| Record modified | 2024-07-11 |
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