| Alternative title | NCAP-1 : Matériau de référence de la protéine de nucléocapside du SRAS-CoV-2 |
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| DOI | Resolve DOI: https://doi.org/10.4224/crm.2021.ncap-1 |
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| Author | Search for: Stocks, Bradley1ORCID identifier: https://orcid.org/0000-0002-7265-9344; Search for: Thibeault, Marie-Pier1; Search for: L'Abbé, Denis1; Search for: Gervais, Christian1; Search for: Pelletier, Alex1; Search for: Stuible, Matthew1; Search for: Durocher, Yves1ORCID identifier: https://orcid.org/0000-0002-2268-4111; Search for: Melanson, Jeremy1ORCID identifier: https://orcid.org/0000-0002-2290-0101 |
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| Affiliation | - National Research Council Canada
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| Format | 3D, Material |
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| Material type | Calibration solution |
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| Subject | Canadian reference material; NCAP-1; SARS-CoV-2 nucleocapsid protein |
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| Abstract | NCAP-1 is a reference material (RM) designed for the development of SARS-CoV-2 nucleocapsid protein detection methods, as well as an antigen source for use in SARS-CoV-2 rapid antigen detection tests. The reference values for NCAP-1 are based on combined results from two orthogonal methods from data generated at the National Research Council of Canada (NRC). A unit of NCAP-1 contains 0.4 mL of SARS-CoV-2 nucleocapsid protein in 50 mM Tris buffer (pH 8) with 150 mM sodium chloride. |
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| Analytes | | Analyte | Quantity | Value | Expanded uncertainty | Unit | Type |
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| SARS-CoV-2 nucleocapsid protein | molar concentration | 10.0 | 1.0 | µmol/L | reference | | SARS-CoV-2 nucleocapsid protein | mass fraction | 0.50 | 0.05 | mg/g | reference | | SARS-CoV-2 nucleocapsid protein | mass concentration (21 oC) | 0.50 | 0.05 | mg/mL | reference |
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| Period of validity | - Valid from 2025-10-16 until 2031-05-31
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| Publication date | 2021-10-01 |
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| Publisher | National Research Council Canada |
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| Copyright statement | - © 2021
National Research Council Canada
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| References | View items (4)- Stocks, Bradley B., Marie-Pier Thibeault, Denis L’Abbé, Matthew Stuible, Yves Durocher, and Jeremy E. Melanson. ‘Production and Characterization of a SARS-CoV-2 Nucleocapsid Protein Reference Material’. ACS Measurement Science Au 2, no. 6 (2 September 2022): 620–28. https://doi.org/10.1021/acsmeasuresciau.2c00050.
- Colwill, Karen, Yannick Galipeau, Matthew Stuible, Christian Gervais, Corey Arnold, Bhavisha Rathod, Kento T Abe, et al. ‘A Scalable Serology Solution for Profiling Humoral Immune Responses to SARS‐CoV‐2 Infection and Vaccination’. Clinical & Translational Immunology 11, no. 3 (January 2022). https://doi.org/10.1002/cti2.1380.
- Veen, Adriaan M. H. van der. ‘Bayesian Analysis of Homogeneity Studies in the Production of Reference Materials’. Accreditation and Quality Assurance 22, no. 6 (2 November 2017): 307–19. https://doi.org/10.1007/s00769-017-1292-6.
- ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. https://doi.org/10.59161/jcgm100-2008e.
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| Export citation | Export as RIS |
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| Collection | Canadian Reference Materials and Methods |
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| Record identifier | 66902293-bff6-4965-9dc8-3715e119811f |
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| Record created | 2021-10-25 |
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| Record modified | 2025-11-20 |
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