| Alternative title | BOTS-1 : Matériau de référence certifié de muscles de bovin contenant des résidus de médicaments vétérinaires |
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| DOI | Resolve DOI: https://doi.org/10.4224/crm.2018.bots-1 |
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| Author | Search for: McRae, Garnet1; Search for: Melanson, Jeremy1ORCID identifier: https://orcid.org/0000-0002-2290-0101; Search for: Meija, Juris1ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: Grinberg, Patricia1ORCID identifier: https://orcid.org/0000-0002-1167-6474; Search for: Shurmer, Bryn2ORCID identifier: https://orcid.org/0000-0002-6896-8603; Search for: Mester, Zoltan1ORCID identifier: https://orcid.org/0000-0002-2377-2615 |
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| Affiliation | - National Research Council Canada
- Canadian Food Inspection Agency
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| Format | 3D, Material |
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| Material type | Matrix material |
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| Subject | Canadian reference material; BOTS-1; chlorpromazine; ciprofloxacin; clenbuterol; dexamethasone; enrofloxacin; meloxicam; ractopamine; sulfadiazine |
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| Abstract | BOTS-1 is a certified reference material (CRM) consisting of bovine muscle tissue that has been naturally contaminated with veterinary drugs. This CRM is designed for use in method development, validation, and quality control for the analysis of veterinary drug residues in bovine muscle or related matrices. |
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| Analytes | | Analyte | Quantity | Value | Expanded uncertainty | Unit | Type |
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| chlorpromazine | mass fraction | 490 | 100 | µg/kg | certified | | ciprofloxacin | mass fraction | 44 | 4.4 | µg/kg | certified | | clenbuterol | mass fraction | 3.3 | 1.4 | µg/kg | certified | | dexamethasone | mass fraction | 9.5 | 0.8 | µg/kg | certified | | enrofloxacin | mass fraction | 57 | 4.8 | µg/kg | certified | | meloxicam | mass fraction | 3.0 | 0.4 | µg/kg | certified | | ractopamine | mass fraction | 12.4 | 1.2 | µg/kg | certified | | sulfadiazine | mass fraction | 2290 | 120 | µg/kg | certified | | water | mass fraction | 5.1 | | g/kg | information |
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| Period of validity | - Valid from 2018-08-01 until 2033-08-31
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| Storage conditions | |
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| Publication date | 2018-08-01 |
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| Publisher | National Research Council Canada |
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| Copyright statement | - © 2018
National Research Council Canada
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| Access condition | |
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| References | View items (5)- McRae, Garnet, Donald M. Leek, Juris Meija, Bryn Shurmer, Steven J. Lehotay, Joachim Polzer, Jeremy E. Melanson, and Zoltan Mester. ‘Production and Certification of BOTS-1: Bovine Muscle–Certified Reference Material for Incurred Veterinary Drug Residues’. Analytical and Bioanalytical Chemistry 416, no. 3 (16 June 2023): 759–71. https://doi.org/10.1007/s00216-023-04794-5.
- Windust, Anthony, Garnet McRae, Juris Meija, Zoltán Mester, Jeremy E Melanson, Meg Croft, Lesley Johnston, et al. ‘High Polarity Analytes in Food - Enrofloxacin and Sulfadiazine in Bovine Tissue (CCQM-K141)’. Metrologia 56, no. 1A (1 January 2019): 08005. https://doi.org/10.1088/0026-1394/56/1a/08005.
- DerSimonian, Rebecca, and Nan Laird. ‘Meta-Analysis in Clinical Trials’. Controlled Clinical Trials 7, no. 3 (September 1986): 177–88. https://doi.org/10.1016/0197-2456(86)90046-2.
- Reference materials – Guidance for characterization and assessment of homogeneity and stability. ISO Guide 35:2017 (1 August 2017). https://www.iso.org/standard/60281.html.
- ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. https://doi.org/10.59161/jcgm100-2008e.
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| Export citation | Export as RIS |
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| Collection | Canadian Reference Materials and Methods |
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| Record identifier | 8986c44d-8e9c-4ede-b619-b082698daefd |
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| Record created | 2018-08-24 |
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| Record modified | 2025-11-20 |
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