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AZA6: Calibration Solution Certified Reference Material for Azaspiracid-6

From National Research Council Canada

Alternative titleAZA6 : Matériau de référence certifié d’une solution d’étalonnage pour l’azaspiracide-6
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DOIResolve DOI: https://doi.org/10.4224/crm.2025.aza6.20230502
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0003-1644-2121; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0002-7746-8432
Affiliation
  1. National Research Council of Canada
Format3D, Material
Material typeCalibration solution
SubjectCanadian reference material; AZA6; azaspiracids; azaspiracid-6; algal toxins
Abstract
CRM-AZA6 is a certified calibration solution for analytical method development and accurate quantitation of AZA6. The concentration is suitable for preparing a dilution series for calibration of instruments such as liquid chromatography–mass spectrometry (LC–MS), and for spiking control samples for recovery experiments.
Analytes
AnalyteQuantityValueExpanded uncertaintyUnitType
azaspiracid-6 and 37-epi-azaspiracid-6mass fraction0.610.05µg/gcertified
azaspiracid-6 and 37-epi-azaspiracid-6mass concentration (15-30 °C)0.480.04µg/mLcertified
azaspiracid-6 and 37-epi-azaspiracid-6concentration (15-30 °C)0.570.05µmol/Lcertified
Period of validity
  • Valid from 2025-09-17
  • 1 year from date of sale
Storage conditions
  • Temperature: -12 °C
Publication date
PublisherNational Research Council of Canada
Copyright statement
  • © 2025 National Research Council of Canada
Access condition
References
View items (8)
  1. Tillmann, Urban, Malte Elbrächter, Bernd Krock, Uwe John, and Allan Cembella. ‘Azadinium SpinosumGen. et Sp. Nov. (Dinophyceae) Identified as a Primary Producer of Azaspiracid Toxins’. European Journal of Phycology 44, no. 1 (February 2009): 63–79. .
  2. McCarron, Pearse, Jane Kilcoyne, Christopher O. Miles, and Philipp Hess. ‘Formation of Azaspiracids-3, -4, -6, and -9 via Decarboxylation of Carboxyazaspiracid Metabolites from Shellfish’. Journal of Agricultural and Food Chemistry 57, no. 1 (4 December 2008): 160–69. .
  3. Satake, Masayuki, Katsuya Ofuji, Hideo Naoki, Kevin J. James, Ambrose Furey, Terry McMahon, Joe Silke, and Takeshi Yasumoto. ‘Azaspiracid, a New Marine Toxin Having Unique Spiro Ring Assemblies, Isolated from Irish Mussels, Mytilus Edulis’. Journal of the American Chemical Society 120, no. 38 (1 September 1998): 9967–68. .
  4. Kenton, Nathaniel T., Daniel Adu‐Ampratwum, Antony A. Okumu, Pearse McCarron, Jane Kilcoyne, Frode Rise, Alistair L. Wilkins, Christopher O. Miles, and Craig J. Forsyth. ‘Stereochemical Definition of the Natural Product (6R,10R,13R, 14R,16R,17R,19S,20S,21R,24S,25S,28S,30S,32R,33R,34R,36S,37S,39R)‐Azaspiracid‐3 by Total Synthesis and Comparative Analyses’. Angewandte Chemie International Edition 57, no. 3 (15 December 2017): 810–13. .
  5. Kilcoyne, Jane, Adela Keogh, Ger Clancy, Patricia LeBlanc, Ian Burton, Michael A. Quilliam, Philipp Hess, and Christopher O. Miles. ‘Improved Isolation Procedure for Azaspiracids from Shellfish, Structural Elucidation of Azaspiracid-6, and Stability Studies’. Journal of Agricultural and Food Chemistry 60, no. 10 (2 March 2012): 2447–55. .
  6. Burton, Ian W., Michael A. Quilliam, and John A. Walter. ‘Quantitative 1H NMR with External Standards: Use in Preparation of Calibration Solutions for Algal Toxins and Other Natural Products’. Analytical Chemistry 77, no. 10 (26 March 2005): 3123–31. .
  7. Wright, Elliott J., Daniel G. Beach, and Pearse McCarron. ‘Non-Target Analysis and Stability Assessment of Reference Materials Using Liquid Chromatography‒high-Resolution Mass Spectrometry’. Analytica Chimica Acta 1201 (April 2022): 339622. .
  8. ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. .
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CollectionCanadian Reference Materials and Methods
Record identifier9fe89556-3585-43bb-8d50-6b37db8dd67a
Record created2025-10-28
Record modified2025-10-28
Date modified: