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[Leu¹]MCLY: Calibration Solution Certified Reference Material for [D-Leu¹]Microcystin-LY

From National Research Council Canada

Alternative title[Leu¹]MCLY : Matériau de référence certifié d’une solution d’étalonnage pour la [D-Leu¹]microcystine-LY
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DOIResolve DOI: https://doi.org/10.4224/crm.2025.leu1mcly.20131003
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-4850-5863; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0001-8537-4439; Search for: 1; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0002-2175-6929; Search for: 1ORCID identifier: https://orcid.org/0000-0002-2670-4220; Search for: 1ORCID identifier: https://orcid.org/0000-0002-7746-8432
Affiliation
  1. National Research Council Canada
Format3D, Material
Material typeCalibration solution
SubjectCanadian reference material; [D-Leu1]microcystin-LY; microcystin; cyanotoxin; cyanobacteria
Abstract
CRM-[Leu¹]MCLY is a certified calibration solution designed for analytical method development and accurate quantitation of [D-Leu¹]MC-LY. The concentration is suitable for preparing a dilution series for calibration of instrumentation, such as liquid chromatography–mass spectrometry (LC–MS), as well as for spiking control samples for recovery experiments.
Analytes
AnalyteQuantityValueExpanded uncertaintyUnitType
[D-Leu¹]microcystin-LYmass fraction8.400.32µg/gcertified
[D-Leu¹]microcystin-LYmass concentration (15-30 °C)7.770.30µg/mLcertified
[D-Leu¹]microcystin-LYconcentration (15-30 °C)7.440.29µmol/Lcertified
[D-Leu¹,Glu(OMe)⁶]microcystin-LYconcentration (15-30 °C)0.24µmol/Linformation
Period of validity
  • Valid from 2025-11-21
  • 1 year from date of sale
Storage conditions
  • Temperature: -12 °C
Publication date
PublisherNational Research Council Canada
Copyright statement
  • © 2025 National Research Council Canada
Access condition
References
View items (7)
  1. LeBlanc, Patricia, Nadine Merkley, Krista Thomas, Nancy I. Lewis, Khalida Békri, Susan LeBlanc Renaud, Frances R. Pick, Pearse McCarron, Christopher O. Miles, and Michael A. Quilliam. ‘Isolation and Characterization of [D-Leu1]Microcystin-LY from Microcystis Aeruginosa CPCC-464’. Toxins 12, no. 2 (23 January 2020): 77. .
  2. Pick, Frances R. ‘Blooming Algae: A Canadian Perspective on the Rise of Toxic Cyanobacteria’. Canadian Journal of Fisheries and Aquatic Sciences 73, no. 7 (July 2016): 1149–58. .
  3. Carmichael, Wayne W. ‘The Toxins of Cyanobacteria’. Scientific American 270, no. 1 (January 1994): 78–86. .
  4. Thomas, Krista, Dominik Wechsler, Yi-Min Chen, Sheila Crain, and Michael A Quilliam. ‘Analysis of Natural Toxins by Liquid Chromatography-Chemiluminescence Nitrogen Detection and Application to the Preparation of Certified Reference Materials’. Journal of AOAC INTERNATIONAL 99, no. 5 (1 September 2016): 1173–84. .
  5. Burton, Ian W., Michael A. Quilliam, and John A. Walter. ‘Quantitative 1H NMR with External Standards: Use in Preparation of Calibration Solutions for Algal Toxins and Other Natural Products’. Analytical Chemistry 77, no. 10 (26 March 2005): 3123–31. .
  6. Thomas, Krista, Ruth Perez, Sabrina Giddings, Isabelle Rajotte, Christopher Miles, and Pearse McCarron. ‘MCLA: Certified Calibration Solution for Microcystin-LA’. National Research Council Canada, 15 July 2022. .
  7. ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. .
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CollectionCanadian Reference Materials and Methods
Record identifiere9e87cfc-aeef-415e-9dae-edaafc582a6d
Record created2025-12-05
Record modified2025-12-18
Date modified: